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Phosphine-activated Lysine Analogues for Fast Chemical Control of Protein Subcellular Localization and Protein SUMOylation
The Staudinger reduction and its variants have exceptional compatibility with live cells, but can be limited by slow kinetics. Here, we report novel small molecule triggers that turn on proteins via a Staudinger reduction/self-immolation cascade with substantially improved kinetics and yields. We ac...
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| Gepubliceerd in: | Chembiochem |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6980333/ https://ncbi.nlm.nih.gov/pubmed/31664790 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900464 |
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