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Direct enzymatic synthesis of a deep-blue fluorescent noncanonical amino acid from azulene and serine
We report a simple, one-step enzymatic synthesis of the blue fluorescent noncanonical amino acid β-(1-azulenyl)-l-alanine (AzAla). Using an engineered tryptophan synthase β-subunit (TrpB), stereochemically pure AzAla can be synthesized at scale starting from commercially available azulene and l-seri...
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| Pubblicato in: | Chembiochem |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6980211/ https://ncbi.nlm.nih.gov/pubmed/31513332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900497 |
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