scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens

We present scMAGeCK, a computational framework to identify genomic elements associated with multiple expression-based phenotypes in CRISPR/Cas9 functional screening that uses single-cell RNA-seq as readout. scMAGeCK outperforms existing methods, identifies genes and enhancers with known and novel fu...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Yang, Lin, Zhu, Yuqing, Yu, Hua, Cheng, Xiaolong, Chen, Sitong, Chu, Yulan, Huang, He, Zhang, Jin, Li, Wei
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
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Method
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6979386/
https://ncbi.nlm.nih.gov/pubmed/31980032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-1928-4
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