Ser100-Phosphorylated RORα Orchestrates CAR and HNF4α to Form Active Chromatin Complex in Response to Phenobarbital to Regulate Induction of CYP2B6

We have previously shown that the retinoid-related orphan receptor alpha (RORα) phosphorylation plays a pivotal role in sulfotransferase 1E1 gene regulation within mouse liver. Here, we found serine 100–phosphorylated RORα orchestrates constitutive androstane receptor (CAR) and hepatocyte nuclear fa...

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Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Fashe, Muluneh, Hashiguchi, Takuyu, Negishi, Masahiko, Sueyoshi, Tatsuya
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2020
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978708/
https://ncbi.nlm.nih.gov/pubmed/31924695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.118273
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