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Epithelial cell senescence induces pulmonary fibrosis through Nanog-mediated fibroblast activation

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease tightly correlated with aging. The pathological features of IPF include epithelial cell senescence and abundant foci of highly activated pulmonary fibroblasts. However, the underlying mechanism between epithelial cell sene...

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Detalhes bibliográficos
Publicado no:Aging (Albany NY)
Main Authors: Chen, Xiang, Xu, Hongyang, Hou, Jiwei, Wang, Hui, Zheng, Yi, Li, Hui, Cai, Hourong, Han, Xiaodong, Dai, Jinghong
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977687/
https://ncbi.nlm.nih.gov/pubmed/31891567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.102613
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