Frontline Science: TNF‐α and GM‐CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K‐γ, and neutrophil proinflammatory responses

Circulating neutrophils are, by necessity, quiescent and relatively unresponsive to acute stimuli. In regions of inflammation, mediators can prime neutrophils to react to acute stimuli with stronger proinflammatory, pathogen‐killing responses. In neutrophils G protein‐coupled receptor (GPCR)‐driven...

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Bibliografiske detaljer
Udgivet i:J Leukoc Biol
Main Authors: Suire, Sabine, Baltanas, Fernando C., Segonds‐Pichon, Anne, Davidson, Keith, Santos, Eugenio, Hawkins, Phillip T., Stephens, Len R.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Spotlight on Leading Edge Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977543/
https://ncbi.nlm.nih.gov/pubmed/30720883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/JLB.2HI0918-359RR
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