Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking

The high demand of the pharmaceutical industry for new modalities to address the diversification of biological targets with large surfaces of interaction led us to investigate the replacement of α-amino acid residues with ureido units at selected positions in peptides to improve potency and generate...

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Publicat a:Chem Sci
Autors principals: Fremaux, Juliette, Venin, Claire, Mauran, Laura, Zimmer, Robert, Koensgen, Florian, Rognan, Didier, Bitsi, Stavroula, Lucey, Maria A., Jones, Ben, Tomas, Alejandra, Guichard, Gilles, Goudreau, Sébastien R.
Format: Artigo
Idioma:Inglês
Publicat: Royal Society of Chemistry 2019
Matèries:
Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977461/
https://ncbi.nlm.nih.gov/pubmed/32015811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc02079a
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