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Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking
The high demand of the pharmaceutical industry for new modalities to address the diversification of biological targets with large surfaces of interaction led us to investigate the replacement of α-amino acid residues with ureido units at selected positions in peptides to improve potency and generate...
में बचाया:
| में प्रकाशित: | Chem Sci |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Royal Society of Chemistry
2019
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6977461/ https://ncbi.nlm.nih.gov/pubmed/32015811 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc02079a |
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