Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking

The high demand of the pharmaceutical industry for new modalities to address the diversification of biological targets with large surfaces of interaction led us to investigate the replacement of α-amino acid residues with ureido units at selected positions in peptides to improve potency and generate...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Chem Sci
Main Authors: Fremaux, Juliette, Venin, Claire, Mauran, Laura, Zimmer, Robert, Koensgen, Florian, Rognan, Didier, Bitsi, Stavroula, Lucey, Maria A., Jones, Ben, Tomas, Alejandra, Guichard, Gilles, Goudreau, Sébastien R.
Format: Artigo
Jezik:Inglês
Izdano: Royal Society of Chemistry 2019
Teme:
Chemistry
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977461/
https://ncbi.nlm.nih.gov/pubmed/32015811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc02079a
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