Functionalized Double Strain-Promoted Stapled Peptides for Inhibiting the p53-MDM2 Interaction

[Image: see text] The Sondheimer dialkyne reagent has previously been employed in strain-promoted double-click cycloadditions with bis-azide peptides to generate stapled peptide inhibitors of protein–protein interactions. The substituted variants of the Sondheimer dialkyne can be used to generate fu...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Sharma, Krishna, Strizhak, Alexander V., Fowler, Elaine, Xu, Wenshu, Chappell, Ben, Sore, Hannah F., Galloway, Warren R. J. D., Grayson, Matthew N., Lau, Yu Heng, Itzhaki, Laura S., Spring, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977200/
https://ncbi.nlm.nih.gov/pubmed/31984273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b03459
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