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Profound weight loss induces reactive astrogliosis in the arcuate nucleus of obese mice

OBJECTIVE: Obesity has been linked to an inflammation like state in the hypothalamus, mainly characterized by reactive gliosis (RG) of astrocytes and microglia. Here, using two diet models or pharmacological treatment, we assessed the effects of mild and drastic weight loss on RG, in the context of...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Harrison, Luke, Pfuhlmann, Katrin, Schriever, Sonja C., Pfluger, Paul T.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977167/
https://ncbi.nlm.nih.gov/pubmed/30979678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.03.009
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