Profound weight loss induces reactive astrogliosis in the arcuate nucleus of obese mice

OBJECTIVE: Obesity has been linked to an inflammation like state in the hypothalamus, mainly characterized by reactive gliosis (RG) of astrocytes and microglia. Here, using two diet models or pharmacological treatment, we assessed the effects of mild and drastic weight loss on RG, in the context of...

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Bibliographic Details
Published in:Mol Metab
Main Authors: Harrison, Luke, Pfuhlmann, Katrin, Schriever, Sonja C., Pfluger, Paul T.
Format: Artigo
Language:Inglês
Published: Elsevier 2019
Subjects:
Brief Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977167/
https://ncbi.nlm.nih.gov/pubmed/30979678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.03.009
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