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Profound weight loss induces reactive astrogliosis in the arcuate nucleus of obese mice

OBJECTIVE: Obesity has been linked to an inflammation like state in the hypothalamus, mainly characterized by reactive gliosis (RG) of astrocytes and microglia. Here, using two diet models or pharmacological treatment, we assessed the effects of mild and drastic weight loss on RG, in the context of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Mol Metab
Hauptverfasser: Harrison, Luke, Pfuhlmann, Katrin, Schriever, Sonja C., Pfluger, Paul T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6977167/
https://ncbi.nlm.nih.gov/pubmed/30979678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2019.03.009
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