The multifunctional peptide DN‐9 produced peripherally acting antinociception in inflammatory and neuropathic pain via μ‐ and κ‐opioid receptors

BACKGROUND AND PURPOSE: Considerable effort has recently been directed at developing multifunctional opioid drugs to minimize the unwanted side effects of opioid analgesics. We have developed a novel multifunctional opioid agonist, DN‐9. Here, we studied the analgesic profiles and related side effec...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Xu, Biao, Zhang, Mengna, Shi, Xuerui, Zhang, Run, Chen, Dan, Chen, Yong, Wang, Zilong, Qiu, Yu, Zhang, Ting, Xu, Kangtai, Zhang, Xiaoyu, Liedtke, Wolfgang, Wang, Rui, Fang, Quan
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976790/
https://ncbi.nlm.nih.gov/pubmed/31444977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14848
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