Antinociceptive Interactions between the Imidazoline I(2) Receptor Agonist 2-BFI and Opioids in Rats: Role of Efficacy at the μ-Opioid Receptor

Although μ-opioids have been reported to interact favorably with imidazoline I(2) receptor (I(2)R) ligands in animal models of chronic pain, the dependence on the μ-opioid receptor ligand efficacy on these interactions had not been previously investigated. This study systematically examined the inte...

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Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Siemian, Justin N., Obeng, Samuel, Zhang, Yan, Zhang, Yanan, Li, Jun-Xu
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2016
Subjects:
Behavioral Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4885507/
https://ncbi.nlm.nih.gov/pubmed/27056847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.232421
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