Mechanical forces induce an asthma gene signature in healthy airway epithelial cells

Bronchospasm compresses the bronchial epithelium, and this compressive stress has been implicated in asthma pathogenesis. However, the molecular mechanisms by which this compressive stress alters pathways relevant to disease are not well understood. Using air-liquid interface cultures of primary hum...

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Publicado en:Sci Rep
Main Authors: Kılıç, Ayşe, Ameli, Asher, Park, Jin-Ah, Kho, Alvin T., Tantisira, Kelan, Santolini, Marc, Cheng, Feixiong, Mitchel, Jennifer A., McGill, Maureen, O’Sullivan, Michael J., De Marzio, Margherita, Sharma, Amitabh, Randell, Scott H., Drazen, Jeffrey M., Fredberg, Jeffrey J., Weiss, Scott T.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976696/
https://ncbi.nlm.nih.gov/pubmed/31969610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57755-8
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