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Mechanical forces induce an asthma gene signature in healthy airway epithelial cells

Bronchospasm compresses the bronchial epithelium, and this compressive stress has been implicated in asthma pathogenesis. However, the molecular mechanisms by which this compressive stress alters pathways relevant to disease are not well understood. Using air-liquid interface cultures of primary hum...

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Bibliografske podrobnosti
izdano v:	Sci Rep
Main Authors:	Kılıç, Ayşe, Ameli, Asher, Park, Jin-Ah, Kho, Alvin T., Tantisira, Kelan, Santolini, Marc, Cheng, Feixiong, Mitchel, Jennifer A., McGill, Maureen, O’Sullivan, Michael J., De Marzio, Margherita, Sharma, Amitabh, Randell, Scott H., Drazen, Jeffrey M., Fredberg, Jeffrey J., Weiss, Scott T.
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Publishing Group UK 2020
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6976696/ https://ncbi.nlm.nih.gov/pubmed/31969610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57755-8
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Mechanical forces induce an asthma gene signature in healthy airway epithelial cells

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