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Mechanical forces induce an asthma gene signature in healthy airway epithelial cells

Bronchospasm compresses the bronchial epithelium, and this compressive stress has been implicated in asthma pathogenesis. However, the molecular mechanisms by which this compressive stress alters pathways relevant to disease are not well understood. Using air-liquid interface cultures of primary hum...

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Τόπος έκδοσης:	Sci Rep
Κύριοι συγγραφείς:	Kılıç, Ayşe, Ameli, Asher, Park, Jin-Ah, Kho, Alvin T., Tantisira, Kelan, Santolini, Marc, Cheng, Feixiong, Mitchel, Jennifer A., McGill, Maureen, O’Sullivan, Michael J., De Marzio, Margherita, Sharma, Amitabh, Randell, Scott H., Drazen, Jeffrey M., Fredberg, Jeffrey J., Weiss, Scott T.
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Publishing Group UK 2020
Θέματα:	Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6976696/ https://ncbi.nlm.nih.gov/pubmed/31969610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57755-8
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Mechanical forces induce an asthma gene signature in healthy airway epithelial cells

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