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Blockade of IL-6 signaling prevents paclitaxel-induced neuropathy in C57Bl/6 mice

The microtubule-stabilizing agent paclitaxel frequently leads to chemotherapy-induced peripheral neuropathy (CIN), which further increases the burden of disease and often necessitates treatment limitations. The pathophysiology of CIN appears to involve both “upstream” effects including altered intra...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Huehnchen, Petra, Muenzfeld, Hannah, Boehmerle, Wolfgang, Endres, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976596/
https://ncbi.nlm.nih.gov/pubmed/31969555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2239-0
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