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Blockade of IL-6 signaling prevents paclitaxel-induced neuropathy in C57Bl/6 mice

The microtubule-stabilizing agent paclitaxel frequently leads to chemotherapy-induced peripheral neuropathy (CIN), which further increases the burden of disease and often necessitates treatment limitations. The pathophysiology of CIN appears to involve both “upstream” effects including altered intra...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Huehnchen, Petra, Muenzfeld, Hannah, Boehmerle, Wolfgang, Endres, Matthias
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976596/
https://ncbi.nlm.nih.gov/pubmed/31969555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2239-0
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