AMPA receptor-mTORC1 signaling activation is required for neuroplastic effects of LY341495 in rat hippocampal neurons

The group II metabotropic glutamate 2/3 (mGlu(2/3)) receptor antagonist LY341495 produces antidepressant-like effects by acting on mammalian target of rapamycin complex 1 (mTORC1) signaling and α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors in rodent. We investigated whether LY341...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Seo, Mi kyoung, Hien, Le Thi, Park, Min Kyung, Choi, Ah Jeong, Seog, Dae-Hyun, Kim, Seong-Ho, Park, Sung Woo, Lee, Jung Goo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6976560/
https://ncbi.nlm.nih.gov/pubmed/31969673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-58017-3
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