S-nitrosylation of connexin43 hemichannels elicits cardiac stress–induced arrhythmias in Duchenne muscular dystrophy mice

Patients with Duchenne muscular dystrophy (DMD) commonly present with severe ventricular arrhythmias that contribute to heart failure. Arrhythmias and lethality are also consistently observed in adult Dmd(mdx) mice, a mouse model of DMD, after acute β-adrenergic stimulation. These pathological featu...

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Publicado en:JCI Insight
Autores principales: Lillo, Mauricio A., Himelman, Eric, Shirokova, Natalia, Xie, Lai-Hua, Fraidenraich, Diego, Contreras, Jorge E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975272/
https://ncbi.nlm.nih.gov/pubmed/31751316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130091
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