Tubular injury triggers podocyte dysfunction by β-catenin–driven release of MMP-7

Proteinuric chronic kidney disease (CKD) remains a major health problem worldwide. While it is well established that the progression of primary glomerular disease induces tubulointerstitial lesions, how tubular injury triggers glomerular damage is poorly understood. We hypothesized that injured tubu...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Tan, Roderick J., Li, Yingjian, Rush, Brittney M., Cerqueira, Débora Malta, Zhou, Dong, Fu, Haiyan, Ho, Jacqueline, Beer Stolz, Donna, Liu, Youhua
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975262/
https://ncbi.nlm.nih.gov/pubmed/31743113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.122399
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