Low-level Cxcr4-haploinsufficient HSC engraftment is sufficient to correct leukopenia in WHIM syndrome mice

Warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome immunodeficiency is caused by autosomal dominant gain-of-function mutations in chemokine receptor CXCR4. Patient WHIM-09 was spontaneously cured by chromothriptic deletion of 1 copy of 164 genes, including the CXCR4(WHIM) al...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Gao, Ji-Liang, Owusu-Ansah, Albert, Paun, Andrea, Beacht, Kimberly, Yim, Erin, Siwicki, Marie, Yang, Alexander, Liu, Qian, McDermott, David H., Murphy, Philip M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975255/
https://ncbi.nlm.nih.gov/pubmed/31687976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132140
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