The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome

WHIM syndrome is a rare congenital immunodeficiency disorder characterized by warts, hypogammaglobulinemia, infections, and myelokathexis (neutropenia because of impaired egress from the BM); most patients also have severe panleukopenia. Because WHIM syndrome is caused by mutations in the chemokine...

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Bibliografische gegevens
Hoofdauteurs: McDermott, David H., Liu, Qian, Ulrick, Jean, Kwatemaa, Nana, Anaya-O'Brien, Sandra, Penzak, Scott R., Filho, Joao Oliveira, Priel, Debra A. Long, Kelly, Corin, Garofalo, Mary, Littel, Patricia, Marquesen, Martha M., Hilligoss, Diane, DeCastro, Rosamma, Fleisher, Thomas A., Kuhns, Douglas B., Malech, Harry L., Murphy, Philip M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2011
Onderwerpen:
Clinical Trials and Observations
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208300/
https://ncbi.nlm.nih.gov/pubmed/21890643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-368084
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