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Guiding the Refinement of Biochemical Knowledgebases with Ensembles of Metabolic Networks and Machine Learning

Mechanistic models explicitly represent hypothesized biological knowledge. As such, they offer more generalizability than data-driven models. However, identifying model curation efforts that improve performance for mechanistic models is nontrivial. Here, we develop a solution to this problem for gen...

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Bibliographic Details
Published in:Cell Syst
Main Authors: Medlock, Gregory L., Papin, Jason A.
Format: Artigo
Language:Inglês
Published: Cell Press 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975163/
https://ncbi.nlm.nih.gov/pubmed/31926940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2019.11.006
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