CRISPR/Cas9-mediated precise genome modification by a long ssDNA template in zebrafish

BACKGROUND: Gene targeting by homology-directed repair (HDR) can precisely edit the genome and is a versatile tool for biomedical research. However, the efficiency of HDR-based modification is still low in many model organisms including zebrafish. Recently, long single-stranded DNA (lssDNA) molecule...

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Detalles Bibliográficos
Publicado en:BMC Genomics
Autores principales: Bai, Haipeng, Liu, Lijun, An, Ke, Lu, Xiaochan, Harrison, Michael, Zhao, Yanqiu, Yan, Ruibin, Lu, Zhijie, Li, Song, Lin, Shuo, Liang, Fang, Qin, Wei
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2020
Materias:
Methodology Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974980/
https://ncbi.nlm.nih.gov/pubmed/31964350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-020-6493-4
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