N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

R-loops are nucleic acid structures formed by an RNA:DNA hybrid and unpaired single stranded DNA that represent a source of genomic instability in mammalian cells(1–4). Here we show that N6-methyladenosine (m(6)A) modification, contributing to different aspects of mRNA metabolism(5, 6), is detectabl...

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Publié dans:Nat Genet
Auteurs principaux: Abakir, Abdulkadir, Giles, Tom C., Cristini, Agnese, Foster, Jeremy M., Dai, Nan, Starczak, Marta, Rubio-Roldan, Alejandro, Li, Miaomiao, Eleftheriou, Maria, Crutchley, James, Flatt, Luke, Young, Lorraine, Gaffney, Daniel J., Denning, Chris, Dalhus, Bjørn, Emes, Richard D., Gackowski, Daniel, Corrêa, Ivan R., Garcia-Perez, Jose L., Klungland, Arne, Gromak, Natalia, Ruzov, Alexey
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974403/
https://ncbi.nlm.nih.gov/pubmed/31844323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0549-x
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