A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses

In pursuit of therapeutics for human polyomaviruses, we identified a peptide derived from the BK polyomavirus (BKV) minor structural proteins VP2/3 that is a potent inhibitor of BKV infection with no observable cellular toxicity. The thirteen-residue peptide binds to major structural protein VP1 wit...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:eLife
Autores principales: Kane, Joshua R, Fong, Susan, Shaul, Jacob, Frommlet, Alexandra, Frank, Andreas O, Knapp, Mark, Bussiere, Dirksen E, Kim, Peter, Ornelas, Elizabeth, Cuellar, Carlos, Hyrina, Anastasia, Abend, Johanna R, Wartchow, Charles A
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974358/
https://ncbi.nlm.nih.gov/pubmed/31960795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50722
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares