A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses

In pursuit of therapeutics for human polyomaviruses, we identified a peptide derived from the BK polyomavirus (BKV) minor structural proteins VP2/3 that is a potent inhibitor of BKV infection with no observable cellular toxicity. The thirteen-residue peptide binds to major structural protein VP1 wit...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Kane, Joshua R, Fong, Susan, Shaul, Jacob, Frommlet, Alexandra, Frank, Andreas O, Knapp, Mark, Bussiere, Dirksen E, Kim, Peter, Ornelas, Elizabeth, Cuellar, Carlos, Hyrina, Anastasia, Abend, Johanna R, Wartchow, Charles A
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Biochemistry and Chemical Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6974358/
https://ncbi.nlm.nih.gov/pubmed/31960795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.50722
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