Modulation of a Pore in the Capsid of JC Polyomavirus Reduces Infectivity and Prevents Exposure of the Minor Capsid Proteins

JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). The viral capsid of JCPyV is composed primarily of the major capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomer...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Nelson, Christian D. S., Ströh, Luisa J., Gee, Gretchen V., O'Hara, Bethany A., Stehle, Thilo, Atwood, Walter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403419/
https://ncbi.nlm.nih.gov/pubmed/25609820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00089-15
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