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Modulation of a Pore in the Capsid of JC Polyomavirus Reduces Infectivity and Prevents Exposure of the Minor Capsid Proteins

JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). The viral capsid of JCPyV is composed primarily of the major capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomer...

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Dades bibliogràfiques
Publicat a:J Virol
Autors principals: Nelson, Christian D. S., Ströh, Luisa J., Gee, Gretchen V., O'Hara, Bethany A., Stehle, Thilo, Atwood, Walter J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403419/
https://ncbi.nlm.nih.gov/pubmed/25609820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00089-15
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