Modulation of a Pore in the Capsid of JC Polyomavirus Reduces Infectivity and Prevents Exposure of the Minor Capsid Proteins

JC polyomavirus (JCPyV) infection of immunocompromised individuals results in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). The viral capsid of JCPyV is composed primarily of the major capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomer...

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Bibliographic Details
Published in:J Virol
Main Authors: Nelson, Christian D. S., Ströh, Luisa J., Gee, Gretchen V., O'Hara, Bethany A., Stehle, Thilo, Atwood, Walter J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403419/
https://ncbi.nlm.nih.gov/pubmed/25609820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00089-15
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