Inflammation-Induced Citrullinated Glucose-Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes

The β-cell has become recognized as a central player in the pathogenesis of type 1 diabetes with the generation of neoantigens as potential triggers for breaking immune tolerance. We report that posttranslationally modified glucose-regulated protein 78 (GRP78) is a novel autoantigen in human type 1...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Buitinga, Mijke, Callebaut, Aïsha, Marques Câmara Sodré, Fernanda, Crèvecoeur, Inne, Blahnik-Fagan, Gabriele, Yang, Mei-Ling, Bugliani, Marco, Arribas-Layton, David, Marré, Meghan, Cook, Dana P., Waelkens, Etienne, Mallone, Roberto, Piganelli, Jon D., Marchetti, Piero, Mamula, Mark J., Derua, Rita, James, Eddie A., Mathieu, Chantal, Overbergh, Lut
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Immunology and Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6973547/
https://ncbi.nlm.nih.gov/pubmed/30348823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0295
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