Homogeneous antibody-drug conjugates: DAR 2 anti-HER2 obtained by conjugation on isolated light chain followed by mAb assembly

Despite advances in medical care, cancer remains a major threat to human health. Antibody-drug conjugates (ADCs) are a promising targeted therapy to overcome adverse side effects to normal tissues. In this field, the current challenge is obtaining homogeneous preparations of conjugates, where a defi...

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Pubblicato in:MAbs
Autori principali: Farràs, Mercè, Miret, Joan, Camps, Marc, Román, Ramón, Martínez, Óscar, Pujol, Xavier, Erb, Stéphane, Ehkirch, Anthony, Cianferani, Sarah, Casablancas, Antoni, Cairó, Jordi Joan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
Soggetti:
Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6973308/
https://ncbi.nlm.nih.gov/pubmed/31876436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1702262
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