High‐throughput compound screen reveals mTOR inhibitors as potential therapeutics to reduce (auto)antibody production by human plasma cells

Antibody production by the B cell compartment is a crucial part of the adaptive immune response. Dysregulated antibody production in the form of autoantibodies can cause autoimmune disease. To date, B‐cell depletion with anti‐CD20 antibodies is commonly applied in autoimmunity, but pre‐existing plas...

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Bibliographic Details
Published in:Eur J Immunol
Main Authors: Tuijnenburg, Paul, aan de Kerk, Daan J., Jansen, Machiel H., Morris, Ben, Lieftink, Cor, Beijersbergen, Roderick L., van Leeuwen, Ester M.M., Kuijpers, Taco W.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2019
Subjects:
Adaptive immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972998/
https://ncbi.nlm.nih.gov/pubmed/31621069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201948241
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