High‐throughput compound screen reveals mTOR inhibitors as potential therapeutics to reduce (auto)antibody production by human plasma cells

Antibody production by the B cell compartment is a crucial part of the adaptive immune response. Dysregulated antibody production in the form of autoantibodies can cause autoimmune disease. To date, B‐cell depletion with anti‐CD20 antibodies is commonly applied in autoimmunity, but pre‐existing plas...

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Bibliografische gegevens
Gepubliceerd in:Eur J Immunol
Hoofdauteurs: Tuijnenburg, Paul, aan de Kerk, Daan J., Jansen, Machiel H., Morris, Ben, Lieftink, Cor, Beijersbergen, Roderick L., van Leeuwen, Ester M.M., Kuijpers, Taco W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
Onderwerpen:
Adaptive immunity
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972998/
https://ncbi.nlm.nih.gov/pubmed/31621069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201948241
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