A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8(+) T cells

Mutations in the common gamma chain (γ(c), CD132, encoded by the IL2RG gene) can lead to B(+)T(−)NK(−) X-linked severe combined immunodeficiency, as a consequence of unresponsiveness to γc-cytokines such as interleukins-2, -7 and -15. Hypomorphic mutations in CD132 may cause combined immunodeficienc...

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Detalhes bibliográficos
Main Authors: Kuijpers, Taco W., van Leeuwen, Ester M.M., Barendregt, Barbara H., Klarenbeek, Paul, aan de Kerk, Daan J., Baars, Paul A., Jansen, Machiel H., de Vries, Niek, van Lier, René A.W., van der Burg, Mirjam
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2013
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696605/
https://ncbi.nlm.nih.gov/pubmed/23403317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.077511
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