A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8(+) T cells

Mutations in the common gamma chain (γ(c), CD132, encoded by the IL2RG gene) can lead to B(+)T(−)NK(−) X-linked severe combined immunodeficiency, as a consequence of unresponsiveness to γc-cytokines such as interleukins-2, -7 and -15. Hypomorphic mutations in CD132 may cause combined immunodeficienc...

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Detaylı Bibliyografya
Asıl Yazarlar: Kuijpers, Taco W., van Leeuwen, Ester M.M., Barendregt, Barbara H., Klarenbeek, Paul, aan de Kerk, Daan J., Baars, Paul A., Jansen, Machiel H., de Vries, Niek, van Lier, René A.W., van der Burg, Mirjam
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Ferrata Storti Foundation 2013
Konular:
Original Articles and Brief Reports
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696605/
https://ncbi.nlm.nih.gov/pubmed/23403317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.077511
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