A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8(+) T cells

Mutations in the common gamma chain (γ(c), CD132, encoded by the IL2RG gene) can lead to B(+)T(−)NK(−) X-linked severe combined immunodeficiency, as a consequence of unresponsiveness to γc-cytokines such as interleukins-2, -7 and -15. Hypomorphic mutations in CD132 may cause combined immunodeficienc...

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Bibliografiset tiedot
Päätekijät: Kuijpers, Taco W., van Leeuwen, Ester M.M., Barendregt, Barbara H., Klarenbeek, Paul, aan de Kerk, Daan J., Baars, Paul A., Jansen, Machiel H., de Vries, Niek, van Lier, René A.W., van der Burg, Mirjam
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Ferrata Storti Foundation 2013
Aiheet:
Original Articles and Brief Reports
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696605/
https://ncbi.nlm.nih.gov/pubmed/23403317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2012.077511
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