Capsid-specific removal of circulating antibodies to adeno-associated virus vectors

Neutralizing antibodies directed against adeno-associated virus (AAV) are commonly found in humans. In seropositive subjects, vector administration is not feasible as antibodies neutralize AAV vectors even at low titers. Consequently, a relatively large proportion of humans is excluded from enrollme...

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發表在:Sci Rep
Main Authors: Bertin, Berangere, Veron, Philippe, Leborgne, Christian, Deschamps, Jack-Yves, Moullec, Sophie, Fromes, Yves, Collaud, Fanny, Boutin, Sylvie, Latournerie, Virginie, van Wittenberghe, Laetitia, Delache, Benoit, Le Grand, Roger, Dereuddre-Bosquet, Nathalie, Benveniste, Olivier, Moullier, Philippe, Masurier, Carole, Merten, Otto, Mingozzi, Federico
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972890/
https://ncbi.nlm.nih.gov/pubmed/31965041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57893-z
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