Structural insight into small molecule action on Frizzleds

WNT-Frizzled (FZD) signaling plays a critical role in embryonic development, stem cell regulation and tissue homeostasis. FZDs are linked to severe human pathology and are seen as a promising target for therapy. Despite intense efforts, no small molecule drugs with distinct efficacy have emerged. He...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Kozielewicz, Paweł, Turku, Ainoleena, Bowin, Carl-Fredrik, Petersen, Julian, Valnohova, Jana, Cañizal, Maria Consuelo Alonso, Ono, Yuki, Inoue, Asuka, Hoffmann, Carsten, Schulte, Gunnar
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6972889/
https://ncbi.nlm.nih.gov/pubmed/31964872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14149-3
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