A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

Class F receptors are considered valuable therapeutic targets due to their role in human disease, but structural changes accompanying receptor activation remain unexplored. Employing population and cancer genomics data, structural analyses, molecular dynamics simulations, resonance energy transfer-b...

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Publicat a:Nat Commun
Autors principals: Wright, Shane C., Kozielewicz, Paweł, Kowalski-Jahn, Maria, Petersen, Julian, Bowin, Carl-Fredrik, Slodkowicz, Greg, Marti-Solano, Maria, Rodríguez, David, Hot, Belma, Okashah, Najeah, Strakova, Katerina, Valnohova, Jana, Babu, M. Madan, Lambert, Nevin A., Carlsson, Jens, Schulte, Gunnar
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368630/
https://ncbi.nlm.nih.gov/pubmed/30737406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08630-2
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