A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

Class F receptors are considered valuable therapeutic targets due to their role in human disease, but structural changes accompanying receptor activation remain unexplored. Employing population and cancer genomics data, structural analyses, molecular dynamics simulations, resonance energy transfer-b...

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Udgivet i:Nat Commun
Main Authors: Wright, Shane C., Kozielewicz, Paweł, Kowalski-Jahn, Maria, Petersen, Julian, Bowin, Carl-Fredrik, Slodkowicz, Greg, Marti-Solano, Maria, Rodríguez, David, Hot, Belma, Okashah, Najeah, Strakova, Katerina, Valnohova, Jana, Babu, M. Madan, Lambert, Nevin A., Carlsson, Jens, Schulte, Gunnar
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368630/
https://ncbi.nlm.nih.gov/pubmed/30737406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08630-2
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