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Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET Assessments

[Image: see text] The WNT signaling system governs critical processes during embryonic development and tissue homeostasis, and its dysfunction can lead to cancer. Details concerning selectivity and differences in relative binding affinities of 19 mammalian WNTs to the cysteine-rich domain (CRD) of t...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Kozielewicz, Paweł, Shekhani, Rawan, Moser, Stefanie, Bowin, Carl-Fredrik, Wesslowski, Janine, Davidson, Gary, Schulte, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8205236/
https://ncbi.nlm.nih.gov/pubmed/34151213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.1c00084
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