Extracellular NAD(+) enhances PARP-dependent DNA repair capacity independently of CD73 activity

Changes in nicotinamide adenine dinucleotide (NAD(+)) levels that compromise mitochondrial function trigger release of DNA damaging reactive oxygen species. NAD(+) levels also affect DNA repair capacity as NAD(+) is a substrate for PARP-enzymes (mono/poly-ADP-ribosylation) and sirtuins (deacetylatio...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wilk, Anna, Hayat, Faisal, Cunningham, Richard, Li, Jianfeng, Garavaglia, Silvia, Zamani, Leila, Ferraris, Davide M., Sykora, Peter, Andrews, Joel, Clark, Jennifer, Davis, Amanda, Chaloin, Laurent, Rizzi, Menico, Migaud, Marie, Sobol, Robert W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971268/
https://ncbi.nlm.nih.gov/pubmed/31959836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57506-9
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados