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Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid
The aldehyde dehydrogenase family 1 member A3 (ALDH1A3) catalyzes the oxidation of retinal to the pleiotropic factor retinoic acid using NAD(+). The level of ALDHs enzymatic activity has been used as a cancer stem cell marker and seems to correlate with tumour aggressiveness. Elevated ALDH1A3 expres...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5069622/ https://ncbi.nlm.nih.gov/pubmed/27759097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35710 |
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