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Dihydroxyacetone exposure alters NAD(P)H, induces mitochondrial stress and autophagy in HEK293T cells

Dihydroxyacetone phosphate (DHAP) is the endogenous by-product of fructose metabolism. Excess DHAP in cells can induce advanced glycation end products and oxidative stress. Dihydroxyacetone (DHA) is the triose precursor to DHAP. DHA is used as the active ingredient in sunless tanning products, inclu...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: Smith, Kelly R., Hayat, Faisal, Andrews, Joel F., Migaud, Marie E., Gassman, Natalie R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6701868/
https://ncbi.nlm.nih.gov/pubmed/31328504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.9b00230
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