JMJD3 and UTX determine fidelity and lineage specification of human neural progenitor cells

Neurogenesis, a highly orchestrated process, entails the transition from a pluripotent to neural state and involves neural progenitor cells (NPCs) and neuronal/glial subtypes. However, the precise epigenetic mechanisms underlying fate decision remain poorly understood. Here, we delete KDM6s (JMJD3 a...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Shan, Yongli, Zhang, Yanqi, Zhao, Yuan, Wang, Tianyu, Zhang, Jingyuan, Yao, Jiao, Ma, Ning, Liang, Zechuan, Huang, Wenhao, Huang, Ke, Zhang, Tian, Su, Zhenghui, Chen, Qianyu, Zhu, Yanling, Wu, Chuman, Zhou, Tiancheng, Sun, Wei, Wei, Yanxing, Zhang, Cong, Li, Chenxu, Su, Shuquan, Liao, Baojian, Zhong, Mei, Zhong, Xiaofen, Nie, Jinfu, Pei, Duanqing, Pan, Guangjin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971254/
https://ncbi.nlm.nih.gov/pubmed/31959746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14028-x
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