Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes

Obesity, caused by the dysfunction of white adipose tissue (WAT), is reportedly accompanied by exacerbation of lipolysis. Perilipin 1 (PLIN1), which forms a coat around lipid droplets, interacts with several lipolysis proteins to regulate lipolysis. While it is known that perilipin family proteins a...

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Published in:Sci Rep
Main Authors: Mizunoe, Yuhei, Kobayashi, Masaki, Hoshino, Shunsuke, Tagawa, Ryoma, Itagawa, Rei, Hoshino, Ayana, Okita, Naoyuki, Sudo, Yuka, Nakagawa, Yoshimi, Shimano, Hitoshi, Higami, Yoshikazu
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971249/
https://ncbi.nlm.nih.gov/pubmed/31959889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57428-6
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