Nutlin-3a suppresses poly (ADP-ribose) polymerase 1 by mechanisms different from conventional PARP1 suppressors in a human breast cancer cell line

Poly (ADP-ribose) polymerase 1 (PARP1) plays important roles in single strand DNA repair. PARP1 inhibitors enhance the effects of DNA damaging drugs in homologous recombination-deficient tumors including tumors with breast cancer susceptibility gene (BRCA1) mutation. Nutlin-3a, an analog of cis-imid...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kobayashi, Masaki, Ishizaki, Yuka, Owaki, Mika, Matsumoto, Yoko, Kakiyama, Yuri, Hoshino, Shunsuke, Tagawa, Ryoma, Sudo, Yuka, Okita, Naoyuki, Akimoto, Kazunori, Higami, Yoshikazu
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210013/
https://ncbi.nlm.nih.gov/pubmed/32405340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27581
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