Transmissible gastroenteritis virus targets Paneth cells to inhibit the self-renewal and differentiation of Lgr5 intestinal stem cells via Notch signaling

Infection with transmissible gastroenteritis virus (TGEV) has been associated with villous atrophy within 48 h, which seriously disrupts intestinal homeostasis. However, the underlying mechanisms remain elusive. In this study, we found that TGEV infection severely disrupted intestinal homeostasis vi...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Wu, Aimin, Yu, Bing, Zhang, Keying, Xu, Zhiwen, Wu, De, He, Jun, Luo, Junqiu, Luo, Yuheng, Yu, Jie, Zheng, Ping, Che, Lianqiang, Mao, Xiangbing, Huang, Zhiqing, Wang, Lan, Zhao, Jun, Chen, Daiwen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6971083/
https://ncbi.nlm.nih.gov/pubmed/31959773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2233-6
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