Loss of Endothelial Endoglin Promotes High-Output Heart Failure Through Peripheral Arteriovenous Shunting Driven by VEGF Signaling

RATIONALE: ENG (endoglin) is a coreceptor for BMP (bone morphogenetic protein) 9/10 and is strongly expressed in endothelial cells. Mutations in ENG lead to the inherited vascular disorder hereditary hemorrhagic telangiectasia characterized by local telangiectases and larger arteriovenous malformati...

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Dettagli Bibliografici
Pubblicato in:Circ Res
Autori principali: Tual-Chalot, Simon, Garcia-Collado, Maria, Redgrave, Rachael E., Singh, Esha, Davison, Benjamin, Park, Catherine, Lin, Hua, Luli, Saimir, Jin, Yi, Wang, Yixin, Lawrie, Allan, Jakobsson, Lars, Arthur, Helen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2020
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6970547/
https://ncbi.nlm.nih.gov/pubmed/31805812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.119.315974
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