Revisiting the tumorigenesis timeline with a data-driven generative model

Cancer is driven by the sequential accumulation of genetic and epigenetic changes in oncogenes and tumor suppressor genes. The timing of these events is not well understood. Moreover, it is currently unknown why the same driver gene change appears as an early event in some cancer types and as a late...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Lahouel, Kamel, Younes, Laurent, Danilova, Ludmila, Giardiello, Francis M., Hruban, Ralph H., Groopman, John, Kinzler, Kenneth W., Vogelstein, Bert, Geman, Donald, Tomasetti, Cristian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2020
Gaiak:
Physical Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969520/
https://ncbi.nlm.nih.gov/pubmed/31882448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914589117
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