Revisiting the tumorigenesis timeline with a data-driven generative model

Cancer is driven by the sequential accumulation of genetic and epigenetic changes in oncogenes and tumor suppressor genes. The timing of these events is not well understood. Moreover, it is currently unknown why the same driver gene change appears as an early event in some cancer types and as a late...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lahouel, Kamel, Younes, Laurent, Danilova, Ludmila, Giardiello, Francis M., Hruban, Ralph H., Groopman, John, Kinzler, Kenneth W., Vogelstein, Bert, Geman, Donald, Tomasetti, Cristian
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Physical Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969520/
https://ncbi.nlm.nih.gov/pubmed/31882448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914589117
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