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The functionally relevant site for paxilline inhibition of BK channels
The tremorgenic fungal alkaloid paxilline (PAX) is a commonly used specific inhibitor of the large-conductance, voltage- and Ca(2+)-dependent BK-type K(+) channel. PAX inhibits BK channels by selective interaction with closed states. BK inhibition by PAX is best characterized by the idea that PAX ga...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6969516/ https://ncbi.nlm.nih.gov/pubmed/31879339 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912623117 |
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